Expression of Her-2/neu oncogene in endometrial carcinoma in OMTH

Objective: This retrospective descriptive study to, assess the expression of Her-2 in endometrial carcinoma & to correlate the results with other known clinic pathologic features in Sudanese patients . Material and Methods: Twenty three (23) paraffin-embedded formalin-fixed tissue blocks of endometrial carcinoma were stained by immunoperoxidase stains for Her-2/neu (DAKO, Denmark), collected with their clinical data from archives of Omdurman Military Teaching Hospital in Khartoum-Sudan ,from January to December 2015. The result was correlated with clinical data. Results: Majority of the endometrial carcinoma were in the (57%) most of them lie between (61-70 years) . Her-2/ neu expressed in (8patients) 34.7% of cases. The most frequent association was with non-endometroid carcinoma 2 cases (100%). Conclusion: HER-2/neu appears it to be expressed in endometrial carcinoma(endometroid & non endometroid especially papillary-serous type).